A research project looking at antibody responses to exposure to antigenic (antibody generating) material led to a human study of the response to Candida albicans Yeast. The study was conducted in 1988 and resulted in a paper “Human Serum Immunoglobulin G, A, M levels in Low Grade Chronic Candidiasis”. The paper was not acceptedby a number of established journals of the time and we published the article in a new journal, Journal of Advancement in Medicine, which was not on Pubmed. Here is a copy of the article. The study shows a positive correlation with increased level of antibody to yeast and response to therapy with oral Nystatin, an antifungal that is not absorbed out of the GI tract.
The article is informative about the various responses of IgG, IgA and IgM to a common antigen. A number of conditions are now identified by using antibody responses to a immune challenge. For example, a response to an immunization with Strep pneumonia is is a commonly used test of immune function.